Search | Virtual Health Library

1.

Cellular architecture of human brain metastases.

Gonzalez, Hugo; Mei, Wenbin; Robles, Isabella; Hagerling, Catharina; Allen, Breanna M; Hauge Okholm, Trine Line; Nanjaraj, Ankitha; Verbeek, Tamara; Kalavacherla, Sandhya; van Gogh, Merel; Georgiou, Stephen; Daras, Mariza; Phillips, Joanna J; Spitzer, Matthew H; Roose, Jeroen P; Werb, Zena.

Cell ; 185(4): 729-745.e20, 2022 02 17.

Article in English | MEDLINE | ID: mdl-35063085

2.

Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling.

Chang, Yating; Manivannan, Praveen; Doosti, Abbas; Lapinski, Philip E; Chen, Di; Roose, Jeroen P; King, Philip D.

J Immunol ; 211(6): 917-922, 2023 09 15.

Article in English | MEDLINE | ID: mdl-37566514

3.

Digital signaling and hysteresis characterize ras activation in lymphoid cells.

Das, Jayajit; Ho, Mary; Zikherman, Julie; Govern, Christopher; Yang, Ming; Weiss, Arthur; Chakraborty, Arup K; Roose, Jeroen P.

Cell ; 136(2): 337-51, 2009 Jan 23.

Article in English | MEDLINE | ID: mdl-19167334

4.

Lost GRP on cytotoxicity?

Roose, Jeroen P.

Nat Immunol ; 17(12): 1339-1340, 2016 11 16.

Article in English | MEDLINE | ID: mdl-27849207

5.

STIM1, PKC-Î´ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.

Limnander, Andre; Depeille, Philippe; Freedman, Tanya S; Liou, Jen; Leitges, Michael; Kurosaki, Tomohiro; Roose, Jeroen P; Weiss, Arthur.

Nat Immunol ; 12(5): 425-33, 2011 May.

Article in English | MEDLINE | ID: mdl-21441934

6.

Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.

Wen, Zhi; Yun, Grant; Hebert, Alexander; Kong, Guangyao; Ranheim, Erik A; Finn, Remington; Rajagoplan, Adhithi; Li, Shuyi; Zhou, Yun; Yu, Mei; Damnernsawad, Alisa; Roose, Jeroen P; Coon, Joshua J; Wen, Renren; Wang, Demin; Zhang, Jing.

Blood ; 137(23): 3259-3271, 2021 06 10.

Article in English | MEDLINE | ID: mdl-33512434

7.

mTOR and other effector kinase signals that impact T cell function and activity.

Myers, Darienne R; Wheeler, Benjamin; Roose, Jeroen P.

Immunol Rev ; 291(1): 134-153, 2019 09.

Article in English | MEDLINE | ID: mdl-31402496

8.

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity.

Baars, Matthijs J D; Douma, Thera; Simeonov, Dimitre R; Myers, Darienne R; Kulhanek, Kayla; Banerjee, Saikat; Zwakenberg, Susan; Baltissen, Marijke P; Amini, Mojtaba; de Roock, Sytze; van Wijk, Femke; Vermeulen, Michiel; Marson, Alexander; Roose, Jeroen P; Vercoulen, Yvonne.

Eur J Immunol ; 51(2): 471-482, 2021 02.

Article in English | MEDLINE | ID: mdl-33065764

9.

T cells: a dedicated effector kinase pathways for every trait?

Bahl, Kriti; Roose, Jeroen P.

Biochem J ; 478(6): 1303-1307, 2021 03 26.

Article in English | MEDLINE | ID: mdl-33755101

10.

Tonic Signals: Why Do Lymphocytes Bother?

Myers, Darienne R; Zikherman, Julie; Roose, Jeroen P.

Trends Immunol ; 38(11): 844-857, 2017 11.

Article in English | MEDLINE | ID: mdl-28754596

11.

Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.

Rooney, Gemma E; Goodwin, Alice F; Depeille, Philippe; Sharir, Amnon; Schofield, Claude M; Yeh, Erika; Roose, Jeroen P; Klein, Ophir D; Rauen, Katherine A; Weiss, Lauren A; Ullian, Erik M.

J Neurosci ; 36(1): 142-52, 2016 Jan 06.

Article in English | MEDLINE | ID: mdl-26740656

12.

A phospholipase C-Î³1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.

Kortum, Robert L; Rouquette-Jazdanian, Alexandre K; Miyaji, Michihiko; Merrill, Robert K; Markegard, Evan; Pinski, John M; Wesselink, Amelia; Nath, Nandan N; Alexander, Clayton P; Li, Wenmei; Kedei, Noemi; Roose, Jeroen P; Blumberg, Peter M; Samelson, Lawrence E; Sommers, Connie L.

J Immunol ; 190(1): 147-58, 2013 Jan 01.

Article in English | MEDLINE | ID: mdl-23209318

13.

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.

Lauchle, Jennifer O; Kim, Doris; Le, Doan T; Akagi, Keiko; Crone, Michael; Krisman, Kimberly; Warner, Kegan; Bonifas, Jeannette M; Li, Qing; Coakley, Kristen M; Diaz-Flores, Ernesto; Gorman, Matthew; Przybranowski, Sally; Tran, Mary; Kogan, Scott C; Roose, Jeroen P; Copeland, Neal G; Jenkins, Nancy A; Parada, Luis; Wolff, Linda; Sebolt-Leopold, Judith; Shannon, Kevin.

Nature ; 461(7262): 411-4, 2009 Sep 17.

Article in English | MEDLINE | ID: mdl-19727076

14.

Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer.

Haderk, Franziska; Chou, Yu-Ting; Cech, Lauren; Fernández-Méndez, Celia; Yu, Johnny; Olivas, Victor; Meraz, Ismail M; Barbosa Rabago, Dora; Kerr, D Lucas; Gomez, Carlos; Allegakoen, David V; Guan, Juan; Shah, Khyati N; Herrington, Kari A; Gbenedio, Oghenekevwe M; Nanjo, Shigeki; Majidi, Mourad; Tamaki, Whitney; Pourmoghadam, Yashar K; Rotow, Julia K; McCoach, Caroline E; Riess, Jonathan W; Gutkind, J Silvio; Tang, Tracy T; Post, Leonard; Huang, Bo; Santisteban, Pilar; Goodarzi, Hani; Bandyopadhyay, Sourav; Kuo, Calvin J; Roose, Jeroen P; Wu, Wei; Blakely, Collin M; Roth, Jack A; Bivona, Trever G.

Nat Commun ; 15(1): 3741, 2024 May 03.

Article in English | MEDLINE | ID: mdl-38702301

15.

Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions.

Karra, Laila; Finger, Anna-Marie; Shechtman, Lauren; Krush, Milana; Huang, Rita Meng-Yao; Prinz, Morgan; Tennvooren, Iliana; Bahl, Kriti; Hysienaj, Lisiena; Gonzalez, Paulina G; Combes, Alexis J; Gonzalez, Hugo; Argüello, Rafael J; Spitzer, Matthew H; Roose, Jeroen P.

bioRxiv ; 2023 Dec 20.

Article in English | MEDLINE | ID: mdl-38187679

16.

Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression.

Jana, Sujata; Brahma, Sandipan; Arora, Sonali; Wladyka, Cynthia L; Hoang, Patrick; Blinka, Steven; Hough, Rowan; Horn, Jessie L; Liu, Yuzhen; Wang, Li-Jie; Depeille, Philippe; Smith, Eric; Montgomery, Robert B; Lee, John K; Haffner, Michael C; Vakar-Lopez, Funda; Grivas, Petros; Wright, Jonathan L; Lam, Hung-Ming; Black, Peter C; Roose, Jeroen P; Ryazanov, Alexey G; Subramaniam, Arvind R; Henikoff, Steven; Hsieh, Andrew C.

Cancer Cell ; 41(5): 853-870.e13, 2023 05 08.

Article in English | MEDLINE | ID: mdl-37084735

17.

SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.

Hysenaj, Lisiena; Little, Samantha; Kulhanek, Kayla; Magnen, Melia; Bahl, Kriti; Gbenedio, Oghenekevwe M; Prinz, Morgan; Rodriguez, Lauren; Andersen, Christopher; Rao, Arjun Arkal; Shen, Alan; Lone, Jean-Christophe; Lupin-Jimenez, Leonard C; Bonser, Luke R; Serwas, Nina K; Mick, Eran; Khalid, Mir M; Taha, Taha Y; Kumar, Renuka; Li, Jack Z; Ding, Vivianne W; Matsumoto, Shotaro; Maishan, Mazharul; Sreekumar, Bharath; Simoneau, Camille; Nazarenko, Irina; Tomlinson, Michael G; Khan, Khajida; von Gottberg, Anne; Sigal, Alex; Looney, Mark R; Fragiadakis, Gabriela K; Jablons, David M; Langelier, Charles R; Matthay, Michael; Krummel, Matthew; Erle, David J; Combes, Alexis J; Sil, Anita; Ott, Melanie; Kratz, Johannes R; Roose, Jeroen P.

Stem Cell Reports ; 18(3): 636-653, 2023 03 14.

Article in English | MEDLINE | ID: mdl-36827975

18.

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.

Prasad, Ashok; Zikherman, Julie; Das, Jayajit; Roose, Jeroen P; Weiss, Arthur; Chakraborty, Arup K.

Proc Natl Acad Sci U S A ; 106(2): 528-33, 2009 Jan 13.

Article in English | MEDLINE | ID: mdl-19098101

19.

Investigating increased hematopoietic stem cell fitness in a novel mouse model.

Karra, Laila; Roose, Jeroen P.

Small GTPases ; 13(1): 7-13, 2022 01.

Article in English | MEDLINE | ID: mdl-33517841

20.

Immediate myeloid depot for SARS-CoV-2 in the human lung.

Magnen, Mélia; You, Ran; Rao, Arjun A; Davis, Ryan T; Rodriguez, Lauren; Simoneau, Camille R; Hysenaj, Lisiena; Hu, Kenneth H; Love, Christina; Woodruff, Prescott G; Erle, David J; Hendrickson, Carolyn M; Calfee, Carolyn S; Matthay, Michael A; Roose, Jeroen P; Sil, Anita; Ott, Melanie; Langelier, Charles R; Krummel, Matthew F; Looney, Mark R.

bioRxiv ; 2022 May 11.

Article in English | MEDLINE | ID: mdl-35592107

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